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Multidrug-resistant Salmonella in poultry: A one health perspective on epidemiology, antimicrobial resistance mechanisms, and mitigation strategies
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N. Rangsaz   , M. Gholami-Ahangaran * , N. Mohseni Abbasabadi |
| Department of Veterinary, Shk.C., Islamic Azad University, Shahrekord, Iran |
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Abstract: (8 Views) |
| The emergence of multidrug-resistant (MDR) Salmonella in poultry has become a major One Health challenge, threatening global food safety, poultry production, international trade, and public health. Intensive poultry production systems, combined with inappropriate and excessive antimicrobial use, have accelerated the selection and dissemination of antimicrobial resistance determinants, primarily through mobile genetic elements such as plasmids, integrons, and transposons. Zoonotic non-typhoidal Salmonella (NTS) serovars, including S. Enteritidis, S. Typhimurium, S. Infantis, and S. Kentucky, are among the leading causes of foodborne infections worldwide, frequently contaminating poultry meat and eggs. In contrast, poultry-adapted serovars such as S. Gallinarum and S. Pullorum are rarely zoonotic but remain responsible for substantial economic losses in the poultry industry. The emergence of MDR strains, particularly those resistant to critically important antimicrobials such as fluoroquinolones and extended-spectrum cephalosporins, has further complicated disease treatment and control. This review synthesizes current knowledge on the epidemiology, antimicrobial resistance mechanisms, diagnostic approaches, and control strategies for both zoonotic and poultry-adapted Salmonella, while highlighting critical gaps in global surveillance and resistance monitoring. Preventive measures, including strengthened farm biosecurity, antimicrobial stewardship, vaccination, routine surveillance, and integrated occupational health and hygiene programs, are essential to reduce pathogen transmission across the food chain. A coordinated One Health approach, supported by genomic surveillance and evidence-based policy interventions, is crucial for controlling MDR Salmonella, protecting public health, and ensuring sustainable poultry production. |
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| Keywords: Multidrug-resistant Salmonella, Poultry, One Health, Antimicrobial resistance, Food safety, Genomic surveillance |
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Full-Text [PDF 439 kb]
(3 Downloads)
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Type of Study: Applicable |
Subject:
General
Received: 2025/12/2 | Published: 2027/01/30
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