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Synergistic Benefits of Hyaluronic Acid and Azelaic Acid on Cutaneous Wound Healing: A Histopathological Analysis
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S. Khanamani Falahatipour   , S. Shokrpoor * , G. Sadeghi Hashjin , M. Mohammadi Mazlaghani |
| Department of Pathobiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran & - |
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Abstract: (12 Views) |
| Cutaneous wounds present significant clinical challenges by compromising the body’s protective barrier. Optimizing wound healing is crucial to enhance patients’ quality of life. Hyaluronic acid (HA) promotes tissue repair, while azelaic acid (AZ) offers anti-inflammatory and antibacterial effects. This study investigates the combined effects of HA and AZ on wound healing. To evaluate the impact of concurrent topical application of HA and AZ on wound healing in a rabbit model. Experimental wounds (6 mm diameter, 2 mm depth) were created in rabbits (n = X) using a skin punch. Wounds were allowed to heal by secondary intention, with HA and AZ applied topically every 12 hours for 14 days. Control wounds received a solution without active ingredients. Tissue samples were collected on days 7 and 14 for histopathological analysis using H&E and Masson’s trichrome staining. The treatment group demonstrated complete epidermal coverage and organized granulation tissue. Histopathological analysis revealed improved collagen deposition and reduced inflammation compared to controls, which exhibited incomplete regeneration and disorganized cellular structures. The combined application of HA and AZ significantly enhanced wound healing, as evidenced by improved epithelialization and collagen organization. These findings suggest the potential clinical applicability of this combination therapy for accelerated wound repair |
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| Keywords: Rabbit, Hyaluronic Acid, Azelaic Acid, Wound Healing, Pathology |
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Type of Study: Research |
Subject:
Special
Received: 2025/04/23
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