en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="line-height:120%"><span style="font-family:Calibri,sans-serif"><span lang="EN" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Cutaneous wounds pose significant clinical challenges by disrupting the body&rsquo;s protective barrier, necessitating optimized healing strategies to improve patient outcomes. Hyaluronic acid (HA) facilitates tissue repair, while azelaic acid (AzA) exhibits anti-inflammatory and antibacterial properties. This study evaluated the synergistic effects of topical HA and AzA on wound healing in a rabbit model. Standardized full-thickness wounds (6 mm diameter, 2 mm depth) were created using a skin punch. Treatments with HA and AzA were applied every 12 hours for 14 days, while control wounds received a placebo solution. Tissue samples were collected on days 7 and 14 for histopathological examination using hematoxylin & eosin and Masson&#39;s trichrome staining. The treatment group showed complete epidermal coverage, well-organized granulation tissue, enhanced collagen deposition, and reduced inflammation compared to controls, which exhibited incomplete regeneration and disorganized cellular structures. These findings demonstrate that combined topical application of HA and AzA significantly accelerates cutaneous wound healing, highlighting its potential clinical utility for improved tissue repair.</span></span></span></span><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span> Rabbit, Hyaluronic Acid, Azelaic Acid, Wound Healing, Pathology 1 12 http://injvr.com/browse.php?a_code=A-10-31-4&slc_lang=en&sid=1 S. Khanamani Falahatipour falahatipour@ut.ac.ir 10031947532846001397 10031947532846001397 No Department of Comparative Bioscience, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran S. Shokrpoor shokrpoor@ut.ac.ir 10031947532846001398 10031947532846001398 Yes Department of Pathobiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran G. Sadeghi Hashjin gsadeghi@ut.ac.ir 10031947532846001399 10031947532846001399 No Department of Comparative Bioscience, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran M. Mohammadi Mazlaghani s.shokrpoor@gmail.com 10031947532846001400 10031947532846001400 No Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran L. Mandrioli 10031947532846001401 10031947532846001401 No Department of Veterinary Medical Sciances, University of Bologna, Italy