College of Health and Medical Techniques, Middle Technical University
Abstract: (523 Views)
Background: Dietary modification is a frequent strategy used in scientific investigations to replicate circumstances related with insulin resistance, obesity, and type 2 diabetes. Objective:This research intended to find out how a high-fructose diet affected glycemic control, antioxidant status, as well as immunological function in male rats. Materials and methods:A group of twenty-four male adult rats was divided at random to four even groups, each composed of six animals. The groupings were categorized as the following: The Negative Control Group comprised rats that received a standard saline. Rats in the Positive Control Group were given solution of a high-fructose (60%) in their drinking water. The rats in the third group received 30 (mg/kg) of acarbose via oral administration. The rats in the fourth group were given 15 mg/kg of metformin orally. Blood samples were taken at the end of the month-long trial to analyze a diverse factors associated with glycemic control and antioxidant status. Results:The results revealed a rise in the glycemic index, Characterized by raised levels of insulin and glucose in the high-fructose treatment group as compared to the control group. However, acarbose treatment has resulted in significant enhancements in glucose regulation, antioxidant status. Conclusion:This study provides a comprehensive analysis of the hyperglycemic effects of fructose and implies that the oral administration of acarbose may serve as a significant intervention to alleviate these effects.
AL-Saeed M, Kasim S, Atiyah D. Evaluation of acarbose and metformin on physiological parameters in diabetic male rat induced by high supplementation of fructose. injvr 2023; 3 (2) :21-37 URL: http://injvr.com/article-1-49-en.html