This case report describes a concurrent infection with canine parvovirus (CPV) and Toxocara canis in a two-month-old male Japanese Spitz crossbred puppy presented to the Veterinary Teaching Hospital of Nepal Polytechnic Institute. The puppy showed severe clinical signs including anorexia, vomiting, mucous-stained hemorrhagic diarrhea, and marked depression. Fecal examination revealed the presence of Toxocara eggs, while CPV infection was confirmed through clinical and pathological findings. Post-mortem examination demonstrated extensive gross lesions, including hepatic congestion, pulmonary congestion with frothy exudates, linear intestinal hemorrhages in the colon, and adult T. canis worms in the small intestine. Histopathological examination revealed interstitial pneumonia with edema, viral enteritis characterized by villous atrophy, congestion of the liver and lungs, and evidence of larval migration associated with inflammation and necrosis. This case highlights the synergistic pathological impact of parasitic and viral coinfections in young puppies and underscores the importance of early diagnosis, routine deworming, and prompt supportive therapy to reduce morbidity and mortality.