en عمومى General پژوهشي Research <span style="font-size:11pt"><span style="line-height:120%"><span style="font-family:Calibri,sans-serif"><b><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Background: </span></span></span></span></b><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">Dietary modification is a frequent strategy used in scientific investigations to replicate circumstances related with insulin resistance, obesity, and type 2 diabetes.<b> </b><span style="color:black">&nbsp;</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:120%"><span style="font-family:Calibri,sans-serif"><b><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Objective:</span></span></span></span></b> <span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">This research intended to find out how a high-fructose diet affected&nbsp;glycemic control, antioxidant status, as well as immunological function in male rats</span></span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">.<span style="color:black"> </span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:120%"><span style="font-family:Calibri,sans-serif"><b><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Materials and methods:</span></span></span></span></b> <span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">A group of twenty-four male adult rats was divided at random to four even&nbsp;groups, each composed of six animals. The groupings were categorized as the following: The Negative Control Group comprised rats that received a standard saline. Rats in the Positive Control Group were given solution of a high-fructose (60%) in their drinking water. The rats in the third group received 30 (mg/kg) of acarbose via oral administration. The rats in the fourth group were given 15 mg/kg of metformin orally. Blood samples were taken at the end of the month-long trial to analyze a diverse factors associated with glycemic control and antioxidant status.<b> </b></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:120%"><span style="font-family:Calibri,sans-serif"><b><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Results:</span></span></span></span></b> <span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">The results revealed a rise in the glycemic index, Characterized by raised levels of insulin and glucose in the high-fructose treatment group as compared to the control group. However, acarbose treatment has resulted in significant enhancements in glucose regulation, antioxidant status. <b><span style="color:black"></span></b></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:120%"><span style="font-family:Calibri,sans-serif"><b><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion:</span></span></span></span></b> <span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">This study provides a comprehensive analysis of the hyperglycemic effects of fructose and implies that the oral administration of acarbose may serve as a significant intervention to alleviate these effects.<b><span style="color:black"></span></b></span></span></span></span></span></span> Acarbose, Diabetic Rat, Fructose, Glycemic index 21 37 http://injvr.com/browse.php?a_code=A-10-37-1&slc_lang=en&sid=1 M.H. AL-Saeed muna.mahmood@uobasrah.edu.iq 1003194753284600462 1003194753284600462 No Department of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Basrah S.F. Kasim sumayah.faruq@mtu.edu.iq 1003194753284600463 1003194753284600463 Yes College of Health and Medical Techniques, Middle Technical University D.I. Atiyah duha.ibraheem@almaaqal.edu.iq 1003194753284600464 1003194753284600464 No College of Pharmacy, almaaqal university