en عمومى General گزارش مورد case report <span style="font-size:11pt"><span style="line-height:120%"><span style="font-family:Calibri,sans-serif"><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="color:black">This case report describes the successful treatment of pyometra caused by multi-drug resistant (MDR) <i>Klebsiella pneumoniae</i> in a 5-year-old Labrador Retriever. Antibiotic susceptibility testing revealed resistance to commonly used antibiotics, including amoxicillin-clavulanate, gentamicin, and ciprofloxacin, but sensitivity to cefoperazone/sulbactam, a third-generation cephalosporin combined with a beta-lactamase inhibitor. The therapeutic regimen involved cefoperazone/sulbactam in combination with trypsin-chymotrypsin enzyme therapy, aimed at enhancing drug efficacy by facilitating necrotic tissue clearance and promoting resolution of inflammation. This combined treatment led to complete clinical recovery, underscoring its potential as an effective alternative for managing severe open pyometra cases when surgical intervention is contraindicated.</span></span></span></span></span></span></span> Cefoperazone-sulbactam, Trypsin-chymotrypsin, Pyometra, Klebsiella pneumoniae, Multi-drug resistant 45 50 http://injvr.com/browse.php?a_code=A-10-68-1&slc_lang=en&sid=1 M. Pal drmayankpalvet@gmail.com 10031947532846001410 10031947532846001410 Yes Veterinary College Anjora Durg A. Aalisha 10031947532846001411 10031947532846001411 No Department of Veterinary Pharmacology and Toxicology, college of Veterinary Science & AH, Anjora, DSVCKV, Durg, Chhattisgarh, India