en تخصصي Special گزارش مورد case report <span style="font-size:11pt"><span style="line-height:120%"><span style="font-family:Calibri,sans-serif"><span lang="EN-GB" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">In recent years mammary gland neoplasm has been recognized in pet and laboratory rabbits. The present study describes the concurrence of two malignant mammary gland neoplasms in a </span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">six-year-old intact female domestic</span></span></span><span lang="EN-GB" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""> rabbit.</span></span></span> <span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">On clinical examination, the masses were observed in the left inguinal and right thoracic mammary glands.</span></span></span> <span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">Based on owner information, the inguinal mammary gland mass within the previous 3-month period, and the thoracic mammary gland mass within the previous 6-month period, had become evident. Finally, complete surgical removal of the masses was selected. Tissue samples of the masses were fixed in 10% neutral buffered formalin and stained with H&E.</span></span></span><span lang="EN-GB" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""> In addition, immunohistochemical studies on masses sections were performed using primary antibodies against cytokeratins AE1/AE3.</span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""> Microscopically, the left mass </span></span></span><span lang="EN-GB" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">was <a name="_Hlk187491672">diagnosed </a>as solid carcinoma, and the right mass was diagnosed as intraductal papillary carcinoma. Immunohistochemistry showed diffuse positive cytoplasmic staining of the neoplastic cells in both of masses with primary antibodies against cytokeratins AE1/AE3. </span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">The best treatment option for mammary masses in pet rabbits is surgical excision, that is performed under general anesthesia. In this case, </span></span></span><span lang="EN-GB" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">no new growth of the masses was observed 4 months following surgical procedures.</span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span> Rabbit, Neoplasia, Mammary gland, Carcinoma, Histopathology 111 116 http://injvr.com/browse.php?a_code=A-10-31-3&slc_lang=en&sid=1 S. Shokrpoor shokrpoor@ut.ac.ir 10031947532846001128 10031947532846001128 Yes Department of Pathobiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran D. Ghaffari s.shokrpoor@gmail.com 10031947532846001129 10031947532846001129 No Department of Pathobiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran M.S. Khanbabaii 10031947532846001130 10031947532846001130 No Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran