fa عمومى General پژوهشي Research <div style="text-align:start"> <div><span style="font-size:16px"><span style="color:#222222"><span helvetica="" neue="" style="font-family:"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="background-color:#ffffff"><span style="text-decoration-thickness:initial"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><font face="Helvetica Neue, Helvetica, Arial, sans-serif"><span style="font-size:16px">The presence of antidepressant residues, such as fluoxetine (FLX), in surface and underground waters worldwide has raised concerns regarding their potential impacts on non-target organisms, including fish. This study aimed to investigate the effects of short-term exposure to environmentally relevant concentrations of FLX on zebrafish (Danio rerio). A total of 120 zebrafish, with an average weight of 0.43&plusmn;0.05 g and length of 3.43&plusmn;0.05 cm, were divided into one control group and four treatment groups exposed to different FLX concentrations (0.1 &mu;g/L, 0.5 &mu;g/L, 10 &mu;g/L, and 100 &mu;g/L) for 96 hours. Histopathological examination was conducted on the gill and kidney tissues to assess the effects of acute FLX exposure. The results revealed structural changes in the gills, including hyperplasia, aneurysm, clubbing, shrinkage, atrophy, and fusion of secondary lamellae. Similarly, the kidney tissues exhibited expansion of Bowman&#39;s space, increased thickness of Bowman&#39;s capsule, dilation of glomerular capillaries, tubular degeneration, and necrosis. The study underscores the toxic effects of FLX on zebrafish at environmentally relevant concentrations in the micrograms per liter range. Therefore, the potential adverse effects of residual FLX exposure should not be overlooked in fish populations.</span></font></span></span></span></span></span></span></span></span></span></span></span></div> </div> Zebra fish, Fluoxetine, Antidepressant, Tissue damages 21 33 http://injvr.com/browse.php?a_code=A-10-1-24&slc_lang=fa&sid=1 A. Rezaeipour 10031947532846001159 10031947532846001159 No Department of Basic science, Science and Research Branch, Islamic Azad University, Tehran, Iran R. Kazempoor 10031947532846001160 10031947532846001160 Yes Department of Aquatic Animal Health and Diseases, Science and Research Branch, Islamic Azad University, Tehran, Iran P. Mortazavi 10031947532846001161 10031947532846001161 No Department of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran A. Ghorbanzadeh 10031947532846001162 10031947532846001162 No Department of Aquatic Animal Health and Diseases, Science and Research Branch, Islamic Azad University, Tehran, Iran