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Evaluation of acarbose and metformin on physiological parameters in diabetic male rat induced by high supplementation of fructose
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M.H. AL-Saeed   , S.F. Kasim * , D.I. Atiyah |
| College of Health and Medical Techniques, Middle Technical University |
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Abstract: (575 Views) |
Background: Dietary modification is a frequent strategy used in scientific investigations to replicate circumstances related with insulin resistance, obesity, and type 2 diabetes.
Objective: This research intended to find out how a high-fructose diet affected glycemic control, antioxidant status, as well as immunological function in male rats.
Materials and methods: A group of twenty-four male adult rats was divided at random to four even groups, each composed of six animals. The groupings were categorized as the following: The Negative Control Group comprised rats that received a standard saline. Rats in the Positive Control Group were given solution of a high-fructose (60%) in their drinking water. The rats in the third group received 30 (mg/kg) of acarbose via oral administration. The rats in the fourth group were given 15 mg/kg of metformin orally. Blood samples were taken at the end of the month-long trial to analyze a diverse factors associated with glycemic control and antioxidant status.
Results: The results revealed a rise in the glycemic index, Characterized by raised levels of insulin and glucose in the high-fructose treatment group as compared to the control group. However, acarbose treatment has resulted in significant enhancements in glucose regulation, antioxidant status.
Conclusion: This study provides a comprehensive analysis of the hyperglycemic effects of fructose and implies that the oral administration of acarbose may serve as a significant intervention to alleviate these effects. |
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| Keywords: Acarbose, Diabetic Rat, Fructose, Glycemic index |
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Full-Text [PDF 495 kb]
(162 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/11/5 | Published: 2023/07/6
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